PhD, Experimental Psychology, Oxford University, 1988
|Department of Psychology
64 Cummington Street
Boston MA 02215
(617) 353-1424 (FAX)
Research in my laboratory focuses on regulation of different dynamical states in cortical networks by modulators such as acetylcholine and norepinephrine.
GABAB modulation and theta rhythm
In physiological experiments, we are exploring how modulatory effects at GABAB receptors could alter network dynamics during different phases of the theta rhythm oscillation in hippocampus. In computational modeling, we've analyzed how changes in strength of transmission within theta cycles could enhance encoding and retrieval of sequences of activity.
Acetylcholine and consolidation
Physiological experiments suggest that cholinergic modulation
suppresses excitatory feedback from hippocampus to neocortex. Removal
of this suppression could allow generation of sharp wave activity
which spreads back to neocortical structures, possibly mediating the
transfer of associations stored in hippocampus to neocortical
structures. We are analyzing this hypothesis in further physiological
and modeling work.
Further information is available at the CBD ongoing research pages.
Hasselmo, M.E., Bodelon, C. and Wyble, B.P. (2001) A proposed function for hippocampal theta rhythm: Separate phases of encoding and retrieval enhance reversal of prior learning. Neural Computation, 14: 1-25.
Wyble, B.P., Linster, C. and Hasselmo, M.E. (2000) Size of CA1-evoked synaptic potentials is related to theta rhythm phase in rat hippocampus. J. Neurophysiol., 83: 2138-2144.
Hasselmo, M.E. (1999) Neuromodulation: Acetylcholine and consolidation. Trends in Cog. Sciences 3: 351-359.
Linster, C., Wyble, B. and Hasselmo, M.E. (1999) Modulation of synaptic potentials in the piriform cortex by electrical stimulation of the horizontal limb of the diagonal band of Broca, J. Neurophysiology 81: 2737-2742.
Hasselmo, M.E. and McClelland, J.L. (1999) Neural models of memory. Curr. Opinion Neurobiol. 9: 184-188.
Patil, M.M. and Hasselmo, M.E. (1999) Modulation of inhibitory synaptic potentials in the piriform cortex. J. Neurophysiol. 81(5):2103-2118.
Wallenstein, G.V., Eichenbaum, H.B. and Hasselmo, M.E. (1998) The hippocampus as an associator of discontiguous events. Trends Neurosci. 21: 317-323.21: 317-323.
Sohal, V.S. and Hasselmo, M.E. (1998) Changes in GABAB modulation during a theta cycle may be analogous to the fall of temperature during annealing. Neural Computation 10: 889-902.
Wallenstein, G.V. and Hasselmo, M.E. (1997) GABAergic modulation of
hippocampal activity: Sequence learning, place field development, and
the phase precession effect. Journal of Neurophysiology,